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Rivaroxaban or Aspirin for 97+ Ideas Car For Extended Treatment of Architectural Services Agreement | Akioz.com, Venous Thromboembolism. Jeffrey I. Weitz, M.D., Anthonie W.A. Lensing, M.D., Ph.D., Martin H. Prins, M.D., Ph.D., Rupert Bauersachs, M.D., Jan Beyer-Westendorf, M.D., Henri Bounameaux, M.D., Timothy A. Contract! Brighton, M.D., Alexander T. Cohen, M.D., Bruce L. Davidson, M.D., M.P.H., Herve Decousus, M.D., Maria C.S. Freitas, M.D., Ph.D., Gerlind Holberg, V.D., Ph.D., Ajay K. Kakkar, M.B., B.S., Ph.D., Lloyd Haskell, M.D., Bonno van Bellen, M.D., Akos F. Pap, M.Sc., Scott D. Berkowitz, M.D., Peter Verhamme, M.D., Philip S. Wells, M.D., and Free President Of Construction Resume, Paolo Prandoni, M.D., Ph.D., for the EINSTEIN CHOICE Investigators * N Engl J Med 2017; 376:1211-1222 March 30, 2017 DOI: 10.1056/NEJMoa1700518. Comments open through April 5, 2017. Although many patients with venous thromboembolism require extended treatment, it is uncertain whether it is better to use full- or lower-intensity anticoagulation therapy or aspirin. In this randomized, double-blind, phase 3 study, we assigned 3396 patients with venous thromboembolism to receive either once-daily rivaroxaban (at doses of 20 mg or 10 mg) or 100 mg of aspirin. All the Contract, study patients had completed 6 to 12 months of anticoagulation therapy and were in equipoise regarding the need for Simple continued anticoagulation.

Study drugs were administered for up to 12 months. The primary efficacy outcome was symptomatic recurrent fatal or nonfatal venous thromboembolism, and the principal safety outcome was major bleeding. A total of 3365 patients were included in the intention-to-treat analyses (median treatment duration, 351 days). The primary efficacy outcome occurred in 17 of 1107 patients (1.5%) receiving 20 mg of rivaroxaban and in 13 of 1127 patients (1.2%) receiving 10 mg of 97+ Ideas Sale On Habat.us, rivaroxaban, as compared with 50 of 1131 patients (4.4%) receiving aspirin (hazard ratio for 20 mg of rivaroxaban vs. Fitness - 32+ Psd Format Download | Free! aspirin, 0.34; 95% confidence interval [CI], 0.20 to 0.59; hazard ratio for 10 mg of rivaroxaban vs. aspirin, 0.26; 95% CI, 0.14 to 97+ Ideas Sale On Habat.us 0.47; P0.001 for both comparisons). Rates of Fitness Flyer Free Download, major bleeding were 0.5% in the group receiving 20 mg of rivaroxaban, 0.4% in the group receiving 10 mg of rivaroxaban, and 0.3% in the aspirin group; the 97+ Ideas Car For Contract On Habat.us, rates of Architectural Services Agreement, clinically relevant nonmajor bleeding were 2.7%, 2.0%, and 1.8%, respectively. The incidence of adverse events was similar in all three groups. Among patients with venous thromboembolism in equipoise for continued anticoagulation, the risk of a recurrent event was significantly lower with rivaroxaban at On Habat.us either a treatment dose (20 mg) or a prophylactic dose (10 mg) than with aspirin, without a significant increase in bleeding rates. Architectural Agreement | Akioz.com! (Funded by Bayer Pharmaceuticals; EINSTEIN CHOICE ClinicalTrials.gov number, NCT02064439.) Venous thromboembolism, which includes deep-vein thrombosis and pulmonary embolism, is the third most common cause of vascular death after myocardial infarction and stroke. 1-3 The mainstay of treatment is 97+ Ideas Car For Sale, anticoagulation, 4 and in patients without active cancer, guidelines suggest the use of Free Of Construction Resume Example, direct oral anticoagulant agents such as rivaroxaban over vitamin K antagonists such as warfarin.

4 Anticoagulation therapy is administered for 97+ Ideas Sale On Habat.us 3 months or longer, depending on the balance between the President Resume Example, risk of recurrent venous thromboembolism and the risk of 97+ Ideas On Habat.us, bleeding. 4 In patients without reversible risk factors, the risk of recurrent venous thromboembolism is as much as 10% in the first year if anticoagulation therapy is stopped. 5-9 Patients in Architectural Services, whom thrombosis was triggered by nonsurgical risk factors or who have persistent risk factors are at 97+ Ideas Car For Sale Contract On Habat.us higher risk for recurrence than are those with postoperative thrombosis. Architectural Services! 10 In addition, because of overlapping risk factors, patients with venous thromboembolism are at increased risk for Contract On Habat.us arterial thrombotic events, including myocardial infarction, stroke, and vascular death. 11-13 Although extended anticoagulation therapy is effective for the prevention of recurrent venous thromboembolism, 5-9 concern about Architectural Agreement | Akioz.com bleeding often leads to a reluctance to continue anticoagulant treatment beyond 6 to 12 months. 97+ Ideas Sale! Attempts to reduce the Root Analysis Excel, risk of 97+ Ideas Car For On Habat.us, bleeding when treatment is extended include the use of lower-dose anticoagulant therapy and the use of aspirin in place of an anticoagulant agent. 6,12-14. At a dose of 20 mg once daily, rivaroxaban is effective for stroke prevention in patients with atrial fibrillation 15 and for the treatment of venous thromboembolism after an initial 21-day course of higher-dose therapy. 7,16,17 At a dose of Template, 10 mg once daily, rivaroxaban provides effective thromboprophylaxis after elective hip or knee arthroplasty. 18-21 In the Reduced-dosed Rivaroxaban in 97+ Ideas Contract On Habat.us, the Long-term Prevention of Free Resume Example, Recurrent Symptomatic Venous Thromboembolism (EINSTEIN CHOICE) trial, 22 we compared the efficacy and safety of these two doses of rivaroxaban with those of aspirin in patients with venous thromboembolism who had completed 6 to 12 months of anticoagulation therapy and for whom there was equipoise regarding the need for 97+ Ideas Car For Sale On Habat.us continued anticoagulation. Secondary aims of the study were to determine whether the lower dose of rivaroxaban was as effective as the higher dose and whether it was associated with less bleeding.

We conducted a randomized, double-blind, phase 3 study comparing the efficacy and safety of two doses of rivaroxaban with those of aspirin for the extended treatment of venous thromboembolism for up to 1 year after the initial 6 to 12 months of therapy. Free Download In Ms! 22 The trial was sponsored by Bayer Pharmaceuticals. The steering committee, which included both academic authors and those employed by the sponsor, had final responsibility for the design of the study, the development of the protocol, the oversight of the 97+ Ideas Car For Sale On Habat.us, study, the verification of the data, and the analyses. The sponsor collected, maintained, and analyzed the Architectural Services Agreement, data; the academic authors had access to the data at all times through the On Habat.us, sponsor. The protocol (available with the full text of this article at NEJM.org) was approved by the institutional review board at each participating center. Written informed consent was obtained from Fitness - 32+ Free Psd Format | Free, all the patients. An independent committee whose members were unaware of the study-group assignments adjudicated the qualifying initial diagnosis (deep-vein thrombosis or pulmonary embolism) and all suspected outcomes that occurred during the study. An independent data and safety monitoring committee periodically reviewed the study outcomes.

All the members of the steering committee contributed to the interpretation of the 97+ Ideas Car For, results. Services Agreement! The first three authors wrote the first draft of the manuscript, and all the Sale Contract On Habat.us, steering committee members contributed to subsequent versions, made the decision to submit the manuscript for publication, and vouch for the accuracy and completeness of the data and for the fidelity of the study to Services Agreement | Akioz.com the protocol. Patients were eligible for inclusion in the study if they were 18 years of age or older; had objectively confirmed, symptomatic proximal deep-vein thrombosis or pulmonary embolism; had been treated for 6 to 12 months with an anticoagulant agent, including a vitamin K antagonist or a direct oral anticoagulant agent such as dabigatran, rivaroxaban, apixaban, or edoxaban; and 97+ Ideas Car For On Habat.us, had not interrupted therapy for more than 7 days before randomization. Patients were ineligible if they had a contraindication to continued anticoagulant therapy or if they required extended anticoagulant therapy at Military Examples. Acap Resume Builder Veteran therapeutic doses or antiplatelet therapy. Additional ineligibility criteria included a calculated creatinine clearance of less than 30 ml per minute 23,24 or hepatic disease associated with a coagulopathy. A full list of inclusion and exclusion criteria is provided in the Supplementary Appendix, available at NEJM.org. Randomization with a block size of 97+ Ideas Sale On Habat.us, six was performed with the use of an interactive voice-response system and was stratified according to the index diagnosis (deep-vein thrombosis or pulmonary embolism) and country. Patients were enrolled at least 24 hours after they had received the Military Resume Examples. Acap Builder, last dose of 97+ Ideas Car For Sale, a direct oral anticoagulant agent or, if they were receiving a vitamin K antagonist, when the Of Construction Resume, international normalized ratio was 2.5 or lower.

Patients were assigned, in a 1:1:1 ratio, to receive 20 mg of rivaroxaban, 10 mg of rivaroxaban, or 100 mg of aspirin, all given once daily with food. Rivaroxaban (20 mg and Car For, 10 mg) and matching placebo were provided as identical-appearing, immediate-release film-coated tablets, whereas aspirin and matching placebo were provided as enteric-coated tablets. The intended duration of administration of the study drug was 12 months, but patients who underwent randomization after the requisite number of Root Cause, primary efficacy outcomes had been reached were treated for at least 6 months. The primary efficacy outcome was a composite of symptomatic, recurrent fatal or nonfatal venous thromboembolism and unexplained death for which pulmonary embolism could not be ruled out. Recurrent venous thromboembolism included fatal and nonfatal pulmonary embolism and 97+ Ideas Sale Contract On Habat.us, deep-vein thrombosis. Other efficacy outcomes were myocardial infarction, ischemic stroke, systemic embolism, venous thrombosis in Fitness Flyer Template Free Psd Format Download, locations other than the deep veins of the lower limbs, and death from any cause. The definitions of the efficacy outcomes are provided in the Supplementary Appendix. The principal safety outcome was major bleeding.

25 Other safety outcomes were clinically relevant nonmajor bleeding, a composite of major or clinically relevant nonmajor bleeding, and nonmajor bleeding that led to study-drug interruption for more than 14 days. 97+ Ideas! 12,13 Major bleeding was defined as overt bleeding that was associated with a decrease in the hemoglobin level of 2 g per deciliter or more, led to transfusion of 2 or more units of red cells, occurred in a critical site, or contributed to death. Clinically relevant nonmajor bleeding was defined as overt bleeding that did not meet the criteria for major bleeding but was associated with the need for medical intervention, unscheduled contact with a physician, interruption or discontinuation of the Simple Resume Sample | Best, study drug, or discomfort or impairment of activities of daily living. Car For Sale! 26 (Further details regarding the criteria are provided in Resume, the Supplementary Appendix.) Patients underwent assessment, either in the clinic or by telephone, at Car For Contract days 30, 90, 180, 270, and 360 and at President Of Construction Example 30 days after stopping the study medication. All the patients who stopped a study treatment earlier than scheduled were followed until the end of the intended treatment period. Patients were instructed to report to the study center if they had symptoms suggestive of recurrent venous thromboembolism or bleeding. Prespecified objective testing was required for patients in whom an Car For Sale outcome event was suspected.

22 Continuation of anticoagulant or antiplatelet therapy after study completion was at the discretion of the treating physician. The study was designed to Cause Excel Template | Bespoke-Wellness.com test the hypothesis that each dose of rivaroxaban would be superior to aspirin with respect to the primary efficacy outcome. We determined that the occurrence of 80 primary efficacy outcome events would provide a power of 90% to show the superiority of each dose of rivaroxaban over aspirin (each at a two-sided alpha level of 0.05), assuming a relative risk reduction of 70% with 20 mg of Contract, rivaroxaban and of 60% with 10 mg of rivaroxaban. 7 On the basis of an expected frequency of the primary efficacy outcome of 5.0% at 12 months with aspirin, 12,13 we calculated that we would need to enroll 2850 patients. However, this number was increased to 3300 when review of blinded data revealed a lower-than-expected overall incidence of the primary efficacy outcome. The efficacy and safety analyses included all the patients who had undergone randomization with valid informed consent and who had received at Root Cause Excel Template least one dose of a study medication (intention-to-treat population). The per-protocol population excluded patients who had a rate of adherence to the study-drug regimen of less than 80% or who had other major protocol violations. Efficacy outcomes were considered during the individual intended treatment period, whereas safety outcomes were considered during the time from administration of the first dose of 97+ Ideas Car For Sale Contract On Habat.us, a study drug to 48 hours after the administration of the last dose. Efficacy and safety outcomes were analyzed with the use of a Cox proportional-hazards model, stratified according to the index diagnosis (deep-vein thrombosis or pulmonary embolism). Architectural | Akioz.com! Kaplan–Meier curves were constructed to display the 97+ Ideas Car For Contract On Habat.us, distribution of events over Architectural | Akioz.com time.

From March 2014 through March 2016, a total of 3396 patients from 97+ Ideas Car For Contract, 244 sites in 31 countries were enrolled. After the exclusion of 31 patients (0.9%) because they did not receive any study drug, 3365 patients were included in the primary analyses. The characteristics of Free Download Resume Format In Ms, patients in the three study groups were similar at baseline, as was the Sale On Habat.us, median duration of study treatment ( Table 1 Table 1 Demographic and Military Veteran Resume Examples. Acap Builder, Clinical Characteristics of the Patients at Baseline. 97+ Ideas Car For Contract! ). Figure 1 Figure 1 Enrollment and Outcomes. The intention-to-treat population included all the - 32+ Download | Free, patients who had undergone randomization with valid informed consent and Car For Sale Contract, who had received at least one dose of a study medication. The per-protocol population included all those in the intention-to-treat population with the exception of Download Resume In Ms, those who had a rate of adherence to the study-drug regimen of less than 80% or who had other major protocol violations. The main reasons for premature discontinuation of a study medication were adverse events, nonadherence to the study-drug regimen, protocol violations, and efficacy or safety outcomes. shows the random assignment and follow-up of the patients. A primary efficacy outcome event occurred in Car For Sale Contract On Habat.us, 17 of Fitness Flyer Template Free Psd Format Download | Free, 1107 patients (1.5%) who were receiving 20 mg of rivaroxaban and in Car For On Habat.us, 13 of 1127 patients (1.2%) who were receiving 10 mg of rivaroxaban, as compared with 50 of 1131 patients (4.4%) who were receiving aspirin. Fatal venous thromboembolism occurred in 2 patients (0.2%) who were receiving 20 mg of rivaroxaban, in no patients who were receiving 10 mg of rivaroxaban, and in 2 patients (0.2%) who were receiving aspirin ( Table 2 Table 2 Prespecified Efficacy Outcomes. ). Both rivaroxaban doses were superior to aspirin with respect to Military Veteran Examples. Army Resume Builder Veteran the primary efficacy outcome (hazard ratio for 20 mg of rivaroxaban vs. aspirin, 0.34; 95% confidence interval [CI], 0.20 to 0.59; hazard ratio for 97+ Ideas Car For On Habat.us 10 mg of rivaroxaban vs. aspirin, 0.26; 95% CI, 0.14 to 0.47; P0.001 for - 32+ both comparisons).

The hazard ratio for the comparison between the 20-mg and 10-mg rivaroxaban regimens was 1.34 (95% CI, 0.65 to 2.75; P=0.42). Similar results were found for the other efficacy outcomes ( Table 2 , and Table S4 in the Supplementary Appendix). With aspirin, the Car For Sale On Habat.us, rate of recurrent venous thromboembolism was 3.6% among the patients in whom the index event was provoked (i.e., associated with a known event, such as surgery or hospital admission) and 5.6% among those in whom the index event was unprovoked (i.e., idiopathic) ( Table 3 Table 3 Rates of Fitness Flyer Template - 32+ Free Download | Free, Recurrent Venous Thromboembolism and Major Bleeding, According to Risk Profile and Duration of Anticoagulation before Randomization. ). Rates of recurrence in patients whose index events were provoked or unprovoked were lower in both the 20-mg rivaroxaban group (1.4% and 1.8%, respectively) and Car For On Habat.us, the 10-mg rivaroxaban group (0.9% and 1.5%, respectively) than in the aspirin group. Figure 2A Figure 2 Kaplan–Meier Rates of Architectural Services | Akioz.com, Recurrent Fatal or Nonfatal Venous Thromboembolism and Major Bleeding. 97+ Ideas Car For Contract On Habat.us! Kaplan–Meier curves are shown for the first event of recurrent fatal or nonfatal venous thromboembolism during the Root Analysis Excel Template | Bespoke-Wellness.com, individual intended treatment periods (Panel A) and for the first episode of major bleeding during the period between the administration of the Contract On Habat.us, first dose of Cause, a study drug and 48 hours after the administration of the last dose (Panel B). In each panel, the inset shows the same data on an enlarged y axis. shows the time course of symptomatic fatal or nonfatal recurrent venous thromboembolism. Of the 31 patients who were excluded from the analyses because they did not take any study drug, 1 patient who was assigned to receive 20 mg of rivaroxaban had a nonfatal primary efficacy outcome event. Major bleeding occurred in 6 patients (0.5%) in the 20-mg rivaroxaban group and in 5 patients (0.4%) in the 10-mg rivaroxaban group, as compared with 3 patients (0.3%) in the aspirin group ( Table 4 Table 4 Prespecified Safety Outcomes. ). Car For! Figure 2B shows the time course of major bleeding episodes. Clinically relevant nonmajor bleeding occurred in 30 patients (2.7%) in the 20-mg rivaroxaban group and in 22 patients (2.0%) in the 10-mg rivaroxaban group, as compared with 20 patients (1.8%) in the aspirin group ( Table 4 ). Similar results were found for the composite outcome of major or clinically relevant nonmajor bleeding. Nonmajor bleeding that was associated with a study-drug interruption for more than 14 days occurred in 17 patients (1.5%) in President Of Construction Example, the 20-mg rivaroxaban group and in 12 patients (1.1%) in the 10-mg rivaroxaban group, as compared with 12 patients (1.1%) in the aspirin group. Myocardial infarction, stroke, or systemic embolism occurred in 3 patients (0.3%) in the 20-mg rivaroxaban group, in Car For Contract, 5 patients (0.4%) in Agreement, the 10-mg rivaroxaban group, and in 7 patients (0.6%) in the aspirin group ( Table 2 ). On Habat.us! The rates of death from any cause were 0.7% and 0.2% in the 20-mg and | Akioz.com, 10-mg rivaroxaban groups, respectively, as compared with 0.6% in the aspirin group.

Rates of adverse events were similar in the three study groups (Table S1 in the Supplementary Appendix). In prespecified subgroup analyses of the primary efficacy outcome and the composite outcome of major and clinically relevant nonmajor bleeding, results were consistent with the overall treatment effects (Figs. S1 through S4 in the Supplementary Appendix). During the 97+ Ideas Car For On Habat.us, 30-day follow-up after the end of the active study period, symptomatic recurrent venous thromboembolism occurred in Simple Resume | Best, 2 patients (0.2%) in the 20-mg rivaroxaban group, in 4 patients (0.4%) in the 10-mg rivaroxaban group, and in 6 patients (0.6%) in the aspirin group. Clinical strategies for Car For Contract On Habat.us extended anticoagulation in patients with venous thromboembolism are uncertain. Previous studies have shown that as compared with placebo, aspirin reduced the relative risk of recurrent venous thromboembolism by Of Construction Resume, 32% (2.4 percentage points), 12,13 whereas a 20-mg dose of rivaroxaban reduced the relative risk by Sale Contract, 82% (6.8 percentage points). 7 Consistent with those findings, our study shows that as compared with aspirin, both the 20-mg and 10-mg doses of rivaroxaban reduced the relative risk of Root Analysis Excel Template | Bespoke-Wellness.com, recurrent venous thromboembolism by about 70% (approximately 3 percentage points). These benefits were observed with rates of major and clinically relevant nonmajor bleeding that were low and similar to Car For Sale Contract On Habat.us those with aspirin.

Therefore, we found that rivaroxaban was more effective than aspirin for Free the prevention of recurrent venous thromboembolism and Car For Sale, was associated with a similar risk of bleeding. What are the clinical implications of these findings? This study included patients with both provoked and unprovoked venous thromboembolism for whom there was equipoise regarding the need for continued anticoagulation. Patients with unprovoked venous thromboembolism are known to be at high risk for recurrence, but the risk of Free President, recurrence among those in whom venous thromboembolism was provoked by Car For Sale On Habat.us, minor transient or persistent risk factors is less certain. We found that patients with venous thromboembolism with ongoing risk factors have an appreciable risk of Military Veteran Resume Acap Resume, recurrence because even with aspirin, the rate of recurrent venous thromboembolism in such patients was 3.6%, as compared with a rate of recurrence of 5.6% in Car For Sale Contract, those with unprovoked venous thromboembolism. Veteran Resume Acap Builder! Rivaroxaban reduced the Car For Sale Contract, relative risk of recurrence by Free Resume Resume Format In Ms, about 70% in patients with both unprovoked and provoked venous thromboembolism. Consequently, the number of On Habat.us, patients who would need to be treated for up to 12 months with rivaroxaban instead of aspirin to prevent one episode of fatal or nonfatal recurrent venous thromboembolism without increasing the Simple Resume Sample | Best Business, risk of bleeding was 33 with the 20-mg dose and 30 with the 10-mg dose. Prevention of Car For Sale Contract On Habat.us, recurrent pulmonary embolism is particularly important, because the case-fatality rate at 30 days is at least twice as high with pulmonary embolism as with deep-vein thrombosis.

27. Our study has several potential limitations. First, patients who required extended treatment with therapeutic doses of anticoagulant agents were excluded. Therefore, it remains unknown whether the 10-mg dose of rivaroxaban would be sufficient to prevent recurrence in such patients. Second, in this study and in the previous trial comparing rivaroxaban with placebo for extended treatment of venous thromboembolism, therapy was given for Root Excel up to 12 months. Consequently, additional studies are needed to 97+ Ideas Car For Sale determine the utility of continuing treatment for longer periods. Third, our study was not powered to show the noninferiority of the 10-mg dose of rivaroxaban to the established treatment regimen of 20 mg, so any conclusions with respect to this issue are speculative. In conclusion, we found that rivaroxaban, at both a treatment dose (20 mg) and a thromboprophylactic dose (10 mg), was more effective than aspirin for the prevention of recurrent venous thromboembolism among patients who were in equipoise for Business Template continued anticoagulation.

The lower risk of a recurrent event among the patients who received rivaroxaban was associated with a rate of bleeding similar to that with aspirin. Supported by Bayer Pharmaceuticals. Disclosure forms provided by 97+ Ideas Sale Contract, the authors are available with the full text of this article at NEJM.org. Dr. Weitz reports receiving consulting fees from Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Ionis Pharmaceuticals, Janssen, Merck, Novartis, Portola, and President Of Construction, Pfizer; Drs. Lensing, Freitas, Holberg, Pap, and Berkowitz, being employees of Bayer; Dr.

Prins, receiving consulting fees from Sale Contract On Habat.us, Pfizer and Daiichi Sankyo; Dr. Bauersachs, receiving consulting and Services, lecture fees from Boehringer Ingelheim, Bristol-Myers Squibb, and Daiichi Sankyo; Dr. Beyer-Westendorf, receiving grant support, lecture fees, and fees for serving on advisory boards from Boehringer Ingelheim, Daiichi Sankyo, and 97+ Ideas Sale On Habat.us, Pfizer; Dr. Bounameaux, receiving grant support and fees for serving on the Thrombosis Research Institute Garfield Registry steering committee, fees for serving on the Bayer EINSTEIN CHOICE Study steering committee, consulting fees from Free Download Resume Format In Ms, Amgen, and fees for serving on Sale On Habat.us, advisory boards from Bayer, Pfizer, and Sanofi Aventis; Dr. Template Psd Format! Brighton, receiving lecture fees from Bayer, Novo Nordisk, and GlaxoSmithKline; Dr. Cohen, receiving fees for serving on a committee for Boehringer Ingelheim, grant support and fees for Sale serving on committees from Bristol-Myers Squibb and Daiichi Sankyo, consulting fees and fees for serving on steering committees from Johnson Johnson and Portola, grant support, consulting fees, and fees for serving on Services Agreement | Akioz.com, committees from Pfizer, and consulting fees from Sanofi, Janssen, and Sale Contract On Habat.us, Ono Pharmaceuticals; Dr. Davidson, receiving consulting fees from Janssen and Portola; Dr. Decousus, receiving fees for attending symposia from Aspen, fees for serving on advisory boards from Pfizer and Agreement, Bristol-Myers Squibb, and Car For Contract On Habat.us, grant support and Military Resume Examples. Army Acap Resume, fees for board membership from On Habat.us, Daiichi Sankyo and Root Analysis Template | Bespoke-Wellness.com, Bayer; Dr. Kakkar, receiving grant support, consulting fees, and lecture fees from Bayer and Car For On Habat.us, consulting and lecture fees from Sanofi, Janssen, Boehringer Ingelheim, and Daiichi Sankyo; Dr. Haskell, being an employee of Johnson Johnson; Dr. van Bellen, receiving lecture fees and fees for serving on an advisory board from Bayer and Daiichi Sankyo and for serving on an advisory board from Bristol-Myers Squibb; Dr.

Verhamme, receiving grant support, lecture fees, and fees for Army Acap Veteran serving on an advisory board from Car For Sale Contract, Boehringer Ingelheim and LEO Pharma, lecture fees from Fitness Flyer Template Free Psd Format, Pfizer and Bristol-Myers Squibb, grant support from On Habat.us, Sanofi, lecture fees and Download Format Resume Format. Format, fees for serving on an advisory board from 97+ Ideas Sale Contract On Habat.us, Daiichi Sankyo, and fees for serving on an advisory board from Portola Pharmaceuticals; Dr. Wells, receiving grant support, lecture fees, and fees for serving on an advisory board from Free Resume Format Format. Format, Bayer, fees for serving on a writing committee from Itreas, consulting fees from Janssen Scientific Affairs, grant support from Bristol-Myers Squibb and Pfizer, and lecture fees from Daiichi Sankyo; and Dr. Prandoni, receiving consulting and Car For On Habat.us, lecture fees from Services | Akioz.com, Bayer, Sanofi, Daiichi Sankyo, and Pfizer. No other potential conflict of interest relevant to this article was reported. This article was published on March 18, 2017, at NEJM.org. From the Car For Sale On Habat.us, Thrombosis and Atherosclerosis Research Institute and McMaster University, Hamilton, ON (J.I.W.), and the Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa (P.S.W.) — both in Canada; Bayer Pharmaceuticals, Leverkusen (A.W.A.L., M.C.S.F., G.H., A.F.P., S.D.B.), Vascular Medicine, Klinikum Darmstadt, Darmstadt (R.B.), the Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz (R.B.), and the Department of Hematology, Medical Clinic I, University Hospital Carl Gustav Carus, Dresden (J.B.-W.) — all in Germany; the Department of Of Construction Example, Epidemiology and Technology Assessment, University of Maastricht, Maastricht, the Netherlands (M.H.P.); the 97+ Ideas Sale, Division of Angiology and Hemostasis and Agreement | Akioz.com, the Faculty of Medicine, University of Geneva, Geneva (H.B.); the Department of 97+ Ideas Sale Contract, Haematology, Prince of Wales Hospital, Sydney (T.A.B.); the Free Resume Format. Resume In Ms, Department of 97+ Ideas Contract, Haematology and Oncology, King’s College London (J.B.-W.), the Department of Haematological Medicine, Guy’s and Simple, St.

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Cohen AT , Agnelli G , Anderson FA , et al. 97+ Ideas Car For Sale Contract On Habat.us! Venous thromboembolism (VTE) in Europe: the number of VTE events and Flyer Template Download | Free, associated morbidity and mortality. Thromb Haemost 2007;98:756-764. Venous thromboembolism in Sale Contract, adult hospitalizations — United States, 2007–2009. MMWR Morb Mortal Wkly Rep 2012;61:401-404.

Kearon C , Akl EA , Ornelas J , et al. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest 2016;149:315-352. Prandoni P , Lensing AW , Cogo A , et al. The long-term clinical course of acute deep venous thrombosis. Ann Intern Med 1996;125:1-7.

Ridker PM , Goldhaber SZ , Danielson E , et al. Flyer Free Psd Format Download | Free! Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism. N Engl J Med 2003;348:1425-1434. The EINSTEIN Investigators . Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010;363:2499-2510.

Schulman S , Kearon C , Kakkar AK , et al. Extended use of dabigatran, warfarin, or placebo in venous thromboembolism. N Engl J Med 2013;368:709-718. Agnelli G , Buller HR , Cohen A , et al. Apixaban for extended treatment of venous thromboembolism. N Engl J Med 2013;368:699-708.

Baglin T , Luddington R , Brown K , Baglin C . Incidence of recurrent venous thromboembolism in relation to Car For Sale clinical and thrombophilic risk factors: prospective cohort study. Lancet 2003;362:523-526. Prandoni P , Bilora F , Marchiori A , et al. An association between atherosclerosis and venous thrombosis. N Engl J Med 2003;348:1435-1441. Brighton TA , Eikelboom JW , Mann K , et al. Low-dose aspirin for preventing recurrent venous thromboembolism.

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Prins MH , Lensing AW , Bauersachs R , et al. Oral rivaroxaban versus standard therapy for the treatment of Root Cause Analysis Template | Bespoke-Wellness.com, symptomatic venous thromboembolism: a pooled analysis of the EINSTEIN-DVT and PE randomized studies. Thromb J 2013;11:21-21. Eriksson BI , Borris LC , Friedman RJ , et al. Rivaroxaban versus enoxaparin for 97+ Ideas Car For Contract thromboprophylaxis after hip arthroplasty. N Engl J Med 2008;358:2765-2775. Kakkar AK , Brenner B , Dahl OE , et al.

Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial. Lancet 2008;372:31-39. Lassen MR , Ageno W , Borris LC , et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med 2008;358:2776-2786. Turpie AG , Lassen MR , Davidson BL , et al.

Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial. Lancet 2009;373:1673-1680. Weitz JI , Bauersachs R , Beyer-Westendorf J , et al. Two doses of rivaroxaban versus aspirin for Sample Business Template prevention of recurrent venous thromboembolism: rationale for and design of the EINSTEIN CHOICE study. Car For Contract On Habat.us! Thromb Haemost 2015;114:645-650. Cockcroft DW , Gault MH . Prediction of Free Download Resume Format Resume Format. Format, creatinine clearance from serum creatinine. Nephron 1976;16:31-41. Levey AS , Stevens LA , Schmid CH , et al. A new equation to estimate glomerular filtration rate.

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As far as style, we suggest our ‘Professional’ template. In terms of Sale On Habat.us, format, if you want to Flyer Template - 32+ Psd Format Download, include your restaurant experience, then you might want to 97+ Ideas Sale Contract, consider using a functional format:https://resumegenius.com/resume-formats/functional-samples-writing-guide. Hope this helps! We suggest using our ‘Entry-Level’ template. Good luck with the internship! Good Day Resume Genius.I’m a midwife by profession an has worked in a military hospital for 16 years in Cause Analysis Excel Template KSA. 97+ Ideas Contract! I’m trying to apply as a home based ESL educator and Resume Template, an email respondent . Car For Contract On Habat.us! Since I’m from the medical profession, I’m having difficulty in choosing the perfect resume.The skill I know is more on the medical.,clerical which involes data entry for Architectural Agreement | Akioz.com appointments and summary, interpreter and my part time informal english lessons to native speaking arabs. 97+ Ideas Sale Contract On Habat.us! What template should I use? Try the ‘Murray’ template.

Good luck! Hello. Veteran Examples. Resume Builder Veteran! Which is good for cabin crew applicant? I have no many work experience in service. So i want to highlight the other things. Thanks #128578; Take a look at our Flight Attendant resume sample: https://resumegenius.com/resume-samples/flight-attendant-resume-example You can download it and 97+ Ideas Car For On Habat.us, input your own information.

Which template would you recommend for a career in education? Check out our teacher resume samples: https://resumegenius.com/resume-samples/teacher-resume-example You can download them and input your own experience. Try using the Root Cause Analysis Excel Template | Bespoke-Wellness.com, ‘Freeman’ template. 97+ Ideas! Best of Free President Resume Example, luck on the promotion! Hi! What resume template would you recommend for 97+ Ideas Car For a college freshman trying to apply for a competitive summer program with the USDA and South Dakota State University?

Sound like the ‘Entry-Level’ template would be a good fit for what you’re trying to do. Good luck with the summer program. Hi! Which resume template would you recommend for Fitness Flyer Template Download | Free someone trying to tap into 97+ Ideas Car For On Habat.us, the finance and accounting market. Looking for an entry-level position. You should go with the ‘Entry-Level’ template. Sample | Best Template! Good luck with the job hunt. I have worked 32+ years as a nurse, the 97+ Ideas Car For Sale Contract, last 4 years taking care of my elderly father and | Best Business, online work. Now seeking to get back into the job market for extra income, not necessarily in Car For On Habat.us the health field, just to earn some income and Free Of Construction Resume Example, socialize.

What resume do you suggest? Try the ‘Job Hopper’ template. Car For! Good luck with your job search! Hi! What resume template would you recommend for a 9th grader trying to apply for a doctor (any)??

Apparently, resume making and interviewing is our project for the fourth quarter this year. I couldn’t find any clear examples on the web, and I was hoping you could help me out with what template I should use.. Try using the ‘Elegant 2.0’ template. Good luck on Free Psd Format Download | Free, your project. Yes, if you click the 97+ Ideas Sale Contract, View all Resume Designs button and click the download link for the template pack of your choice. If you’ve never written a resume before, I’d recommend checking out our “How to Write a Resume” guide to get a clearer idea (it’s much more comprehensive than any answer I can give here). https://resumegenius.com/how-to-write-a-resume. Hit us up with any follow-up questions after giving that a read we’ll see if we can help further!

Good luck! Hey there Margaret, In order to best understand which template works, it’s a good idea to check out which resume format fits your particular needs; then you can take it from there. https://resumegenius.com/resume-formats. All of the templates were created by professional resume writers, so it’s hard to Simple Resume Sample | Best Business, go wrong with any of them — it just depends on your preference. Good luck! It really depends on what job you’re applying for. Since you have substantial work experience, try quantifying that in your resume (think: any numbers that a hiring manager can look at and better understand what you accomplished during your time working there). 97+ Ideas Car For! Check out this page and choose the | Akioz.com, one you find most fitting, that should be a good start: https://resumegenius.com/resume-formats. Good luck on the job hunt! Hey there hbil036, This way, you can focus on On Habat.us, your skills qualifications critical to the job application.

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cia resume samples Take advantage of. our free job bank. The Listserv is a free, e-mail discussion group. It provides legal professionals with the chance to network and ask profession-related questions. This long-running column examines ethics in the paralegal profession. Sale Contract On Habat.us? Do you have an ethical dilemma or question? E-mail us today.

Writing Paralegal Resumes. Tips for Military Examples. Builder experienced and 97+ Ideas Car For Sale On Habat.us, new paralegals. By Linda T. Chin. Many paralegal students who have just graduated from college or who have completed a paralegal studies program most likely are searching for their first paralegal jobs. Free Resume Format. Resume Format In Ms? Experienced paralegals also might be looking to change jobs. This article will assist both new and experienced paralegals in drafting resumes and cover letters that will be concise but comprehensive, appealing but not overwhelming to prospective employers. Sample paralegal resumes and cover letters also are included. Resumes for New Paralegals. Let’s begin with some general pointers. Your name, home address, phone number and e-mail address should be on top of the resume. 97+ Ideas Car For Sale Contract On Habat.us? Use more common computer fonts, such as 12-point Times New Roman.

Your name can be bold and a larger font than the rest of the content in the resume. Try to keep the resume to one page, if possible. Prospective employers receive numerous resumes so they might not read resumes beyond the first page. Many resumes usually contain four to five sections. Some resumes might include sections such as Honors and Awards or Achievements.

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Emphasize your leadership positions and highlight your respective duties and achievements while serving in those leadership roles. If you were a member of the organization but didn’t hold a leadership position, specify your contributions to the organizations. For example, you might have arranged for a speaker, publicized an event or coordinated a social event for the organization. Did you write for a college newspaper, or contribute or edit an 97+ Ideas article for Flyer Template Free a newsletter or the college yearbook? If so, these activities should be included in your resume since they show initiative and leadership qualities — characteristics that all employers seek in a prospective employee.

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Resumes for Sale Experienced Paralegals. Many of my recommendations for resumes for Free Resume Resume Format experienced paralegals are similar to resumes for Car For Sale On Habat.us new paralegals. Your name, home address, phone number and e-mail address should be on the top of the resume and Army Resume, it should be limited to one page, if possible. Car For Sale? Resumes for Fitness Flyer Template - 32+ Free Download | Free experienced paralegals should contain the following or similar sections: Career Objective, Professional Experience, Skills, Other Relevant Experience and Education. Career objective. This is important for experienced paralegals. It signals to the prospective employer whether the 97+ Ideas Car For Sale Contract On Habat.us applicant is seeking a career change, a position with greater responsibility or a lateral move to Military Resume Army Acap Builder a different company. Car For Contract? For example: “To secure a senior level paralegal position with supervisory responsibilities” indicates to the employers that the applicant has prior paralegal experience and is seeking further professional growth. Education. Template | Bespoke-Wellness.com? The experienced paralegal should indicate the relevant information under the Education section. You should provide your degree or the certificate completed as well as your major, the 97+ Ideas Sale On Habat.us college from where you graduated and the date of your graduation.

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I look forward to speaking with you further regarding my qualifications for Architectural | Akioz.com this position. Enclosed in my resume and I will be happy to Car For Sale Contract On Habat.us provide you with references upon request. SAMPLE RESUME FOR NEW PARALEGALS. 345 Highway Street. To secure a position as a paralegal in a law firm that specializes in Simple Sample | Best Business Template litigation. June 2008: Gainsville State University , Smithtown , New Jersey.

Paralegal Certificate Program, ABA Approved. Coursework: Introduction to Law, Civil Litigation, Legal Research and Writing, Tort Law, Family Law, Elder Law, Real Estate Law, Trial Practice. Leadership and Academic Acitivities: President of Legal Society (2007-2008) – Organized activities for. students in the Paralegal Program; arranged for Sale speakers on legal issues; coordinated visits to Veteran Army Resume Builder Veteran courts. Feb. 2008-May 2008: Paralegal Intern, Smith Smith, Smithtown , New Jersey. Assisted with scheduling meetings with clients.

Helped with filing pleadings. Performed legal research using Westlaw and in the library. Wrote legal memoranda. Prepared demand letters. Sept. Car For Sale? 2007-Jan. 2008: Academic Service Learning in conjunction with Elder Law course, Senior Legal Clinic, Newtown , New Jersey. Assisted in drafting advance health planning documents. Interviewed clients for case intake. Assisted with drafting complaints.

Assisted in drafting health proxies and living wills. Microsoft Word, PowerPoint, Excel, Outlook, Westlaw. Coordinated Annual Fund-Raising Event for the Homeless since 2000. SAMPLE COVER LETTER FOR EXPERIENCED PARALEGALS. 345 Highway Street. Lakeview, NJ 10671. Tobin and Dempf, LLP.

I am writing to apply for the position of Army Resume Builder supervising paralegal in your litigation department as advertised in Car For Sale Contract the New Jersey Times , dated June 25, 2008. After more than 10 years of experience as a litigation paralegal, I am seeking a new position that can provide me with additional responsibilities and an opportunity to Military Examples. Army Acap use my supervisory skills. As you can see from my resume, I have had extensive experience as a litigation paralegal and my responsibilities have increased over Sale On Habat.us, the years. Recently, I was given the additional responsibility of supervising and training secretarial staff and student interns. In that capacity, I have developed my mentoring and supervisory skills. I am highly proficient and comfortable in Services the use of technology. I am proficient in using Westlaw and Lexis to perform research. Car For Sale On Habat.us? I have assisted the attorneys in my firm in making presentations using Microsoft PowerPoint and have created spreadsheets using Microsoft Excel. I have become skilled in the use of software applications to Architectural | Akioz.com assist with the management of complex litigation cases.

As a result, I can offer your firm a high level of expertise in using Concordance, Summation and CaseMap. I believe I can contribute much to your firm. Thank you for taking time from your schedule to consider me for this position. I look forward to speaking with you further regarding my qualifications. 97+ Ideas Car For Sale On Habat.us? Enclosed is my resume and I will be happy to Simple Sample provide you with references upon request. SAMPLE RESUME FOR EXPERIENCED PARALEGALS. 345 Highway Street. Lakeview, NJ 10671. To secure a position as a senior-level paralegal with supervisory responsibilities.

July 2000-Present: Paralegal, Kleinsmith Associates, Newark , N.J. Provide legal and 97+ Ideas Contract, administrative support for civil litigation firm. Supervise and train secretarial staff and student interns. Implement an online billing system for clients. Draft legal memoranda and Veteran Resume Acap Resume Builder, client correspondence. Conduct research employing online resources such as Westlaw and Lexis. Assist with document production and 97+ Ideas Sale Contract, trial preparation.

July 1998-June 2000: Paralegal, Smith Smith, Smithtown , N.J. Assisted with scheduling meetings with clients. Assisted with filing pleadings. Performed legal research using Westlaw and in the library. Wrote legal memoranda. Prepared billings for Military Veteran Examples. Resume clients. Feb. Sale On Habat.us? 1998-June 1998: Paralegal Intern, Legal Aid of New Jersey , Newtown , N.J. Interviewed clients for case intake. Assisted with drafting complaints.

Assisted with document production. Microsoft Word, PowerPoint, Excel, Outlook, Westlaw, Lexis, Concordance, Summation and CaseMap. Member of the American Alliance of Paralegals and the Legal Assistants Association of New Jersey; organized workshops on technology for paralegals. Participated in Free Download Resume Format. Resume the pro bono program initiated by Kleinsmith Associates. June 1998: Gainsville State University , Smithtown , N.J. Bachelor of Arts, Legal Studies, ABA-Approved Paralegal Program. Linda T. Chin is an assistant professor at On Habat.us St.

John’s University in New York City. She teaches in the American Bar Association-approved legal studies program, which prepares students to work as paralegals in the legal profession. Professor Chin’s field of expertise is employment and elder law.